觉得该用isn't there,因为There is nothing in the bottle句中的否定不是对谓语的否定。如She is unhappy, isn't she?
而He hardly ever has time to play games these days, does he? 这里有对谓语的否定。
供参考
isn't it?
innit?(口语)
There is nothing in the bottle,is there?
因为有个nothing,所以不能用isn't there
应用 is there?
Is there?
Is there anything in the bottle?